Drug interactions
Cyclizine + Solifenacin
Severity: Moderate
Cyclizine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is an antihistamine with anticholinergic activity, which adds to the antimuscarinic effects of solifenacin. Dry mouth, drowsiness, constipation, urinary retention, and confusion may be more pronounced.
What this interaction means in plain words
Cyclizine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic effects, particularly in elderly patients, and limit duration of cyclizine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Solifenacin?
MediHelp rates the interaction as moderate. Cyclizine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is an antihistamine with anticholinergic activity, which adds to the antimuscarinic effects of solifenacin. Dry mouth, drowsiness, constipation, urinary retention, and confusion may be more pronounced.
How serious is the interaction between Cyclizine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly in elderly patients, and limit duration of cyclizine where possible.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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