Drug interactions
Cyclizine + Temazepam
Severity: Moderate
Cyclizine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine hypnotic and cyclizine is a sedating antihistamine, so together they can cause increased drowsiness, impaired coordination and next-day psychomotor impairment. Risk is higher in older adults.
What this interaction means in plain words
Cyclizine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and histamine H1 blockade.
What to do
Use the lowest effective doses and monitor for oversedation. Warn against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Cyclizine with Temazepam?
MediHelp rates the interaction as moderate. Cyclizine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam is a benzodiazepine hypnotic and cyclizine is a sedating antihistamine, so together they can cause increased drowsiness, impaired coordination and next-day psychomotor impairment. Risk is higher in older adults.
How serious is the interaction between Cyclizine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation. Warn against driving and alcohol use.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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