Drug interactions
Cyclizine + Ziconotide
Severity: Moderate
Cyclizine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide, given intrathecally, commonly causes sedation, dizziness and confusion, and the sedating antihistamine cyclizine may add to these effects. Cognitive impairment from ziconotide can be serious, so extra depressant load is undesirable.
What this interaction means in plain words
Cyclizine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression and cognitive impairment from N-type calcium channel blockade and H1 antagonism.
What to do
Monitor for oversedation and changes in mental status. Reduce or stop cyclizine if cognitive effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Cyclizine with Ziconotide?
MediHelp rates the interaction as moderate. Cyclizine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide, given intrathecally, commonly causes sedation, dizziness and confusion, and the sedating antihistamine cyclizine may add to these effects. Cognitive impairment from ziconotide can be serious, so extra depressant load is undesirable.
How serious is the interaction between Cyclizine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and changes in mental status. Reduce or stop cyclizine if cognitive effects emerge.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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