Drug interactions
Cyclobenzaprine + Dantrolene
Severity: Moderate
Cyclobenzaprine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce muscle tone and cause drowsiness and dizziness, so combined use can increase sedation and weakness. Dantrolene also carries a risk of hepatotoxicity, which is a separate concern when polypharmacy is used.
What this interaction means in plain words
Cyclobenzaprine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression and muscle relaxation.
What to do
Monitor sedation, weakness and liver function if dantrolene is continued. Counsel patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Dantrolene
Frequently asked questions
Can I take Cyclobenzaprine with Dantrolene?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs reduce muscle tone and cause drowsiness and dizziness, so combined use can increase sedation and weakness. Dantrolene also carries a risk of hepatotoxicity, which is a separate concern when polypharmacy is used.
How serious is the interaction between Cyclobenzaprine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, weakness and liver function if dantrolene is continued. Counsel patients to avoid driving until the response is known.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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