Drug interactions
Cyclobenzaprine + Hyoscyamine
Severity: Moderate
Cyclobenzaprine and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block muscarinic receptors, so their combination can cause additive anticholinergic effects including dry mouth, constipation, urinary retention, blurred vision, tachycardia, and confusion. Heat intolerance and delirium are particular concerns in older people.
What this interaction means in plain words
Cyclobenzaprine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Hyoscyamine belongs to Genitourinary.
Why it happens
Additive antimuscarinic activity.
What to do
Monitor for anticholinergic toxicity and use the lowest effective doses, or choose a non-anticholinergic alternative in older patients. Avoid in narrow-angle glaucoma, ileus, or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Cyclobenzaprine with Hyoscyamine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents block muscarinic receptors, so their combination can cause additive anticholinergic effects including dry mouth, constipation, urinary retention, blurred vision, tachycardia, and confusion. Heat intolerance and delirium are particular concerns in older people.
How serious is the interaction between Cyclobenzaprine and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and use the lowest effective doses, or choose a non-anticholinergic alternative in older patients. Avoid in narrow-angle glaucoma, ileus, or urinary retention.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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