Drug interactions
Cyclobenzaprine + Indacaterol
Severity: Moderate
Cyclobenzaprine and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and can cause tachycardia and QT prolongation. Together with a beta-2 agonist, the risk of palpitations and arrhythmias may rise in susceptible patients.
What this interaction means in plain words
Cyclobenzaprine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and adrenergic cardiovascular effects with tricyclic-like activity.
What to do
Limit cyclobenzaprine to short courses and monitor heart rate and ECG in patients with cardiac disease or QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Indacaterol?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and can cause tachycardia and QT prolongation. Together with a beta-2 agonist, the risk of palpitations and arrhythmias may rise in susceptible patients.
How serious is the interaction between Cyclobenzaprine and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit cyclobenzaprine to short courses and monitor heart rate and ECG in patients with cardiac disease or QT risk factors.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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