Drug interactions
Cyclobenzaprine + Mirtazapine
Severity: Moderate
Cyclobenzaprine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic and sedating properties, so serotonin syndrome is possible, although risk with mirtazapine is lower than with reuptake inhibitors. Sedation and anticholinergic effects are also additive.
What this interaction means in plain words
Cyclobenzaprine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects and additive CNS depression from antihistaminic and anticholinergic activity.
What to do
Monitor for serotonin toxicity and excessive sedation, and counsel on driving. Reduce doses if drowsiness or confusion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Mirtazapine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic and sedating properties, so serotonin syndrome is possible, although risk with mirtazapine is lower than with reuptake inhibitors. Sedation and anticholinergic effects are also additive.
How serious is the interaction between Cyclobenzaprine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and excessive sedation, and counsel on driving. Reduce doses if drowsiness or confusion develops.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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