Drug interactions
Cyclobenzaprine + Risperidone
Severity: Moderate
Cyclobenzaprine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and cyclobenzaprine adds anticholinergic effects, so drowsiness, dizziness and orthostatic hypotension may increase. Both can prolong the QT interval, and serotonergic effects of cyclobenzaprine may contribute in rare cases.
What this interaction means in plain words
Cyclobenzaprine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and possible additive QT prolongation.
What to do
Monitor sedation and blood pressure, especially in older patients. Check an ECG if other QT-prolonging drugs or cardiac risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Cyclobenzaprine with Risperidone?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and cyclobenzaprine adds anticholinergic effects, so drowsiness, dizziness and orthostatic hypotension may increase. Both can prolong the QT interval, and serotonergic effects of cyclobenzaprine may contribute in rare cases.
How serious is the interaction between Cyclobenzaprine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, especially in older patients. Check an ECG if other QT-prolonging drugs or cardiac risk factors are present.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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