Drug interactions
Cyclobenzaprine + Rizatriptan
Severity: Moderate
Cyclobenzaprine and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine has serotonergic activity, so with rizatriptan there is a theoretical risk of serotonin syndrome. Reported cases are rare and the risk is considered low.
What this interaction means in plain words
Cyclobenzaprine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects of cyclobenzaprine reuptake inhibition and triptan 5-HT1B/1D agonism.
What to do
The combination can be used if needed; counsel patients to report agitation, tremor, sweating or fever. Stop both drugs if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Rizatriptan?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine has serotonergic activity, so with rizatriptan there is a theoretical risk of serotonin syndrome. Reported cases are rare and the risk is considered low.
How serious is the interaction between Cyclobenzaprine and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used if needed; counsel patients to report agitation, tremor, sweating or fever. Stop both drugs if serotonin syndrome is suspected.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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