Drug interactions
Cyclobenzaprine + Stiripentol
Severity: Moderate
Cyclobenzaprine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can inhibit and induce several CYP enzymes including CYP1A2, a pathway involved in cyclobenzaprine metabolism, so cyclobenzaprine exposure may change unpredictably. Stiripentol also causes somnolence, adding to cyclobenzaprine's sedative effects.
What this interaction means in plain words
Cyclobenzaprine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Altered CYP1A2-mediated metabolism by stiripentol combined with additive CNS depression.
What to do
Start cyclobenzaprine at a low dose and monitor for sedation, anticholinergic effects or reduced efficacy, adjusting dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Cyclobenzaprine with Stiripentol?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can inhibit and induce several CYP enzymes including CYP1A2, a pathway involved in cyclobenzaprine metabolism, so cyclobenzaprine exposure may change unpredictably. Stiripentol also causes somnolence, adding to cyclobenzaprine's sedative effects.
How serious is the interaction between Cyclobenzaprine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start cyclobenzaprine at a low dose and monitor for sedation, anticholinergic effects or reduced efficacy, adjusting dose accordingly.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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