Drug interactions
Cyclobenzaprine + Tedizolid
Severity: Moderate
Cyclobenzaprine and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor and cyclobenzaprine has serotonergic activity, so serotonin syndrome is theoretically possible. Clinical data with tedizolid show a low serotonergic signal, but cyclobenzaprine itself is contraindicated with MAOIs.
What this interaction means in plain words
Cyclobenzaprine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Tedizolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effects through weak MAO inhibition by tedizolid and serotonin reuptake inhibition by cyclobenzaprine.
What to do
Prefer an alternative muscle relaxant during tedizolid therapy if feasible. If both are given, monitor for agitation, clonus, hyperthermia and autonomic instability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Cyclobenzaprine with Tedizolid?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is a weak reversible MAO inhibitor and cyclobenzaprine has serotonergic activity, so serotonin syndrome is theoretically possible. Clinical data with tedizolid show a low serotonergic signal, but cyclobenzaprine itself is contraindicated with MAOIs.
How serious is the interaction between Cyclobenzaprine and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative muscle relaxant during tedizolid therapy if feasible. If both are given, monitor for agitation, clonus, hyperthermia and autonomic instability.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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