Drug interactions
Cyclobenzaprine + Tiotropium-olodaterol
Severity: Moderate
Cyclobenzaprine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and has anticholinergic activity that adds to tiotropium. It may also prolong the QT interval and increase heart rate, adding to the cardiovascular effects of olodaterol.
What this interaction means in plain words
Cyclobenzaprine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive cardiac effects (QT prolongation and tachycardia).
What to do
Monitor for anticholinergic effects and palpitations, and use the lowest effective cyclobenzaprine dose. Obtain an ECG if cardiac risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and has anticholinergic activity that adds to tiotropium. It may also prolong the QT interval and increase heart rate, adding to the cardiovascular effects of olodaterol.
How serious is the interaction between Cyclobenzaprine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and palpitations, and use the lowest effective cyclobenzaprine dose. Obtain an ECG if cardiac risk factors are present.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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