Drug interactions
Cyclobenzaprine + Vortioxetine
Severity: Major
Cyclobenzaprine and Vortioxetine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine has multimodal serotonergic activity and cyclobenzaprine also enhances serotonergic neurotransmission. Together they can increase the risk of serotonin syndrome.
What this interaction means in plain words
Cyclobenzaprine and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclobenzaprine belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects via reuptake inhibition and serotonin receptor modulation.
What to do
Avoid if possible and use a non-serotonergic muscle relaxant. If combined, monitor for tremor, clonus, agitation and hyperthermia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Vortioxetine?
MediHelp rates the interaction as major. Cyclobenzaprine and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vortioxetine has multimodal serotonergic activity and cyclobenzaprine also enhances serotonergic neurotransmission. Together they can increase the risk of serotonin syndrome.
How serious is the interaction between Cyclobenzaprine and Vortioxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use a non-serotonergic muscle relaxant. If combined, monitor for tremor, clonus, agitation and hyperthermia.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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