Drug interactions
Cyclophosphamide + Digoxin
Severity: Moderate
Cyclophosphamide and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy can damage the intestinal mucosa, and oral digoxin tablets given with cyclophosphamide have shown reduced absorption and lower serum digoxin concentrations. This may lead to loss of heart rate or heart failure control.
What this interaction means in plain words
Cyclophosphamide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Digoxin belongs to Cardiovascular.
Why it happens
Chemotherapy-induced injury to the gut mucosa reduces absorption of oral digoxin.
What to do
Monitor serum digoxin levels and clinical response during chemotherapy cycles, and consider digoxin solution or capsules or the intravenous route if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Cyclophosphamide with Digoxin?
MediHelp rates the interaction as moderate. Cyclophosphamide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytotoxic chemotherapy can damage the intestinal mucosa, and oral digoxin tablets given with cyclophosphamide have shown reduced absorption and lower serum digoxin concentrations. This may lead to loss of heart rate or heart failure control.
How serious is the interaction between Cyclophosphamide and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and clinical response during chemotherapy cycles, and consider digoxin solution or capsules or the intravenous route if levels fall.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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