Drug interactions
Cyclophosphamide + Erythromycin lactobionate
Severity: Minor
Cyclophosphamide and Erythromycin lactobionate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and may alter cyclophosphamide metabolism, affecting both activation and formation of toxic by-products. The net clinical effect is uncertain and likely small.
What this interaction means in plain words
Cyclophosphamide and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclophosphamide belongs to Oncology; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Erythromycin CYP3A4 inhibition may alter cyclophosphamide metabolic pathways; net effect is not well established.
What to do
No empirical dose change; monitor for myelosuppression and treatment response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Erythromycin lactobionate?
MediHelp rates the interaction as minor. Cyclophosphamide and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intravenous erythromycin inhibits CYP3A4 and may alter cyclophosphamide metabolism, affecting both activation and formation of toxic by-products. The net clinical effect is uncertain and likely small.
How serious is the interaction between Cyclophosphamide and Erythromycin lactobionate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor for myelosuppression and treatment response.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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