Drug interactions
Cyclophosphamide + Etanercept
Severity: Major
Cyclophosphamide and Etanercept: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining etanercept with cyclophosphamide has been associated with a higher rate of non-cutaneous solid malignancies in patients with granulomatosis with polyangiitis. Both drugs also increase susceptibility to infection.
What this interaction means in plain words
Cyclophosphamide and Etanercept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Etanercept belongs to Musculoskeletal.
Why it happens
Additive immunosuppression; the basis for the increased malignancy risk is not established.
What to do
Avoid combining them. If both are needed, monitor closely for infection and perform appropriate malignancy surveillance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclophosphamide
Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Etanercept?
MediHelp rates the interaction as major. Cyclophosphamide and Etanercept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining etanercept with cyclophosphamide has been associated with a higher rate of non-cutaneous solid malignancies in patients with granulomatosis with polyangiitis. Both drugs also increase susceptibility to infection.
How serious is the interaction between Cyclophosphamide and Etanercept?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them. If both are needed, monitor closely for infection and perform appropriate malignancy surveillance.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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