Drug interactions
Cyclophosphamide + Fedratinib
Severity: Moderate
Cyclophosphamide and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4, CYP2C19 and CYP2D6 and may alter the metabolism of cyclophosphamide. Because cyclophosphamide activation depends mainly on CYP2B6 with CYP2C19 and CYP3A4 contributions, the net clinical effect is uncertain but could shift exposure to active or toxic metabolites.
What this interaction means in plain words
Cyclophosphamide and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and CYP2C19 by fedratinib may alter cyclophosphamide bioactivation and clearance.
What to do
Monitor for myelosuppression, infection and signs of cyclophosphamide toxicity, as well as reduced efficacy. Dose adjustment is not routinely defined; adjust based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Cyclophosphamide with Fedratinib?
MediHelp rates the interaction as moderate. Cyclophosphamide and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4, CYP2C19 and CYP2D6 and may alter the metabolism of cyclophosphamide. Because cyclophosphamide activation depends mainly on CYP2B6 with CYP2C19 and CYP3A4 contributions, the net clinical effect is uncertain but could shift exposure to active or toxic metabolites.
How serious is the interaction between Cyclophosphamide and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myelosuppression, infection and signs of cyclophosphamide toxicity, as well as reduced efficacy. Dose adjustment is not routinely defined; adjust based on clinical response.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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