Drug interactions
Cyclophosphamide + Lopinavir
Severity: Moderate
Cyclophosphamide and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, co-formulated with ritonavir, inhibits CYP3A4 and may alter cyclophosphamide metabolism. The net effect on activation versus inactivation is uncertain and could change efficacy or toxicity.
What this interaction means in plain words
Cyclophosphamide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by ritonavir-boosted lopinavir may alter cyclophosphamide metabolism.
What to do
Monitor blood counts and for signs of cyclophosphamide toxicity such as infection, mucositis and urotoxicity. Consider an alternative antiretroviral regimen if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Lopinavir?
MediHelp rates the interaction as moderate. Cyclophosphamide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, co-formulated with ritonavir, inhibits CYP3A4 and may alter cyclophosphamide metabolism. The net effect on activation versus inactivation is uncertain and could change efficacy or toxicity.
How serious is the interaction between Cyclophosphamide and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of cyclophosphamide toxicity such as infection, mucositis and urotoxicity. Consider an alternative antiretroviral regimen if feasible.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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