Drug interactions
Cyclophosphamide + Ocrelizumab
Severity: Major
Cyclophosphamide and Ocrelizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function, and giving them together increases the risk of serious infection. The risk persists after cyclophosphamide is stopped because of lasting lymphocyte effects.
What this interaction means in plain words
Cyclophosphamide and Ocrelizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Ocrelizumab belongs to Central Nervous System.
Why it happens
Additive immunosuppression from B-cell depletion and cytotoxic lymphocyte suppression.
What to do
Avoid concomitant use where possible and monitor for infection, with consideration of lymphocyte and immunoglobulin levels. Screen for hepatitis B before ocrelizumab.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclophosphamide
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Cyclophosphamide with Ocrelizumab?
MediHelp rates the interaction as major. Cyclophosphamide and Ocrelizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, and giving them together increases the risk of serious infection. The risk persists after cyclophosphamide is stopped because of lasting lymphocyte effects.
How serious is the interaction between Cyclophosphamide and Ocrelizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible and monitor for infection, with consideration of lymphocyte and immunoglobulin levels. Screen for hepatitis B before ocrelizumab.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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