Drug interactions
Cyclophosphamide + Oxycodone
Severity: Minor
Cyclophosphamide and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide is a CYP3A4 substrate and prodrug and is not an established inhibitor of CYP3A4, so a significant effect on oxycodone is unlikely. Any interaction would be theoretical.
What this interaction means in plain words
Cyclophosphamide and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclophosphamide belongs to Oncology; Oxycodone belongs to Musculoskeletal.
Why it happens
Possible competition at CYP3A4 or weak modulation; not established clinically.
What to do
No specific action is needed beyond routine monitoring of opioid effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclophosphamide and Oxycodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Oxycodone?
MediHelp rates the interaction as minor. Cyclophosphamide and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclophosphamide is a CYP3A4 substrate and prodrug and is not an established inhibitor of CYP3A4, so a significant effect on oxycodone is unlikely. Any interaction would be theoretical.
How serious is the interaction between Cyclophosphamide and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of opioid effect.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
