Drug interactions
Cyclophosphamide + Rucaparib
Severity: Moderate
Cyclophosphamide and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor and also inhibits CYP2C9, CYP2C19 and CYP1A2. These enzymes help activate cyclophosphamide, so inhibition could lower active metabolite formation. Both agents also cause myelosuppression, which is additive.
What this interaction means in plain words
Cyclophosphamide and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
CYP inhibition by rucaparib may reduce cyclophosphamide bioactivation, and both drugs cause additive bone marrow suppression.
What to do
Monitor complete blood counts regularly. Adjust doses based on hematologic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclophosphamide and Rucaparib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclophosphamide
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Cyclophosphamide with Rucaparib?
MediHelp rates the interaction as moderate. Cyclophosphamide and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate CYP3A4 inhibitor and also inhibits CYP2C9, CYP2C19 and CYP1A2. These enzymes help activate cyclophosphamide, so inhibition could lower active metabolite formation. Both agents also cause myelosuppression, which is additive.
How serious is the interaction between Cyclophosphamide and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly. Adjust doses based on hematologic toxicity.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
