Drug interactions
Cyclophosphamide + Stiripentol
Severity: Moderate
Cyclophosphamide and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes, including CYP2B6, CYP2C19 and CYP3A4, all involved in cyclophosphamide activation. Active metabolite exposure could therefore rise or fall unpredictably. Toxicity or loss of efficacy could result.
What this interaction means in plain words
Cyclophosphamide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP2B6, CYP2C19 and CYP3A4 by stiripentol alters cyclophosphamide activation.
What to do
Monitor blood counts, urinary toxicity and response. Adjust cyclophosphamide based on observed effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Stiripentol
Frequently asked questions
Can I take Cyclophosphamide with Stiripentol?
MediHelp rates the interaction as moderate. Cyclophosphamide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces several CYP enzymes, including CYP2B6, CYP2C19 and CYP3A4, all involved in cyclophosphamide activation. Active metabolite exposure could therefore rise or fall unpredictably. Toxicity or loss of efficacy could result.
How serious is the interaction between Cyclophosphamide and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, urinary toxicity and response. Adjust cyclophosphamide based on observed effect.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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