Drug interactions
Cyclosporin + Dupilumab
Severity: Minor
Cyclosporin and Dupilumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blocking IL-4/IL-13 signalling with dupilumab may reverse cytokine-mediated suppression of CYP enzymes. This could lower cyclosporin concentrations after dupilumab is started, or raise them when it is stopped.
What this interaction means in plain words
Cyclosporin and Dupilumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Dupilumab belongs to Respiratory.
Why it happens
Normalisation of cytokine-suppressed CYP3A4 expression as inflammation is controlled.
What to do
Monitor cyclosporin trough levels and clinical response when starting or stopping dupilumab, adjusting the dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Dupilumab
Frequently asked questions
Can I take Cyclosporin with Dupilumab?
MediHelp rates the interaction as minor. Cyclosporin and Dupilumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Blocking IL-4/IL-13 signalling with dupilumab may reverse cytokine-mediated suppression of CYP enzymes. This could lower cyclosporin concentrations after dupilumab is started, or raise them when it is stopped.
How serious is the interaction between Cyclosporin and Dupilumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporin trough levels and clinical response when starting or stopping dupilumab, adjusting the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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