Drug interactions
Cyclosporin + Eletriptan
Severity: Moderate
Cyclosporin and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may increase eletriptan exposure, raising the risk of vasoconstrictive and other adverse effects. Eletriptan labeling restricts use with strong CYP3A4 inhibitors, and cyclosporin is a weaker inhibitor of CYP3A4.
What this interaction means in plain words
Cyclosporin and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Eletriptan belongs to Central Nervous System.
Why it happens
Cyclosporin inhibits CYP3A4-mediated eletriptan metabolism.
What to do
Use the lowest effective eletriptan dose and watch for blood pressure rise and chest symptoms; consider an alternative triptan not dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Cyclosporin with Eletriptan?
MediHelp rates the interaction as moderate. Cyclosporin and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin may increase eletriptan exposure, raising the risk of vasoconstrictive and other adverse effects. Eletriptan labeling restricts use with strong CYP3A4 inhibitors, and cyclosporin is a weaker inhibitor of CYP3A4.
How serious is the interaction between Cyclosporin and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eletriptan dose and watch for blood pressure rise and chest symptoms; consider an alternative triptan not dependent on CYP3A4.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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