Drug interactions
Cyclosporin + Entecavir
Severity: Minor
Cyclosporin and Entecavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated mainly by the kidneys through filtration and tubular secretion, and cyclosporine can impair renal function. Reduced renal function could increase entecavir exposure. The effect is usually modest but relevant in transplant recipients with fluctuating renal function.
What this interaction means in plain words
Cyclosporin and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Entecavir belongs to Anti Virals.
Why it happens
Cyclosporine nephrotoxicity may reduce renal clearance of entecavir, which is renally eliminated.
What to do
Monitor renal function regularly and adjust the entecavir dose to creatinine clearance if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Entecavir
Frequently asked questions
Can I take Cyclosporin with Entecavir?
MediHelp rates the interaction as minor. Cyclosporin and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated mainly by the kidneys through filtration and tubular secretion, and cyclosporine can impair renal function. Reduced renal function could increase entecavir exposure. The effect is usually modest but relevant in transplant recipients with fluctuating renal function.
How serious is the interaction between Cyclosporin and Entecavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function regularly and adjust the entecavir dose to creatinine clearance if renal function declines.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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