Drug interactions
Cyclosporin + Erythromycin lactobionate
Severity: Major
Cyclosporin and Erythromycin lactobionate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin increases cyclosporine concentrations and the risk of nephrotoxicity, neurotoxicity and hypertension. Cyclosporine may in turn raise erythromycin levels, adding QT risk.
What this interaction means in plain words
Cyclosporin and Erythromycin lactobionate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Erythromycin inhibits CYP3A4 and P-glycoprotein, decreasing cyclosporine metabolism and efflux.
What to do
Use an alternative antibiotic where feasible. If needed, monitor cyclosporine trough levels, creatinine and ECG, and adjust the cyclosporine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Cyclosporin with Erythromycin lactobionate?
MediHelp rates the interaction as major. Cyclosporin and Erythromycin lactobionate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin increases cyclosporine concentrations and the risk of nephrotoxicity, neurotoxicity and hypertension. Cyclosporine may in turn raise erythromycin levels, adding QT risk.
How serious is the interaction between Cyclosporin and Erythromycin lactobionate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where feasible. If needed, monitor cyclosporine trough levels, creatinine and ECG, and adjust the cyclosporine dose.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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