Drug interactions
Cyclosporin + Estradiol
Severity: Moderate
Cyclosporin and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may increase estradiol concentrations, and estrogens may in turn raise cyclosporin levels. This can cause estrogenic adverse effects and cyclosporin toxicity.
What this interaction means in plain words
Cyclosporin and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Estradiol belongs to Endocrine.
Why it happens
Competition for and inhibition of CYP3A4 metabolism, with possible P-glycoprotein effects.
What to do
Monitor cyclosporin trough levels and renal function when estradiol is started or stopped, and watch for estrogen excess such as breast tenderness or hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Cyclosporin with Estradiol?
MediHelp rates the interaction as moderate. Cyclosporin and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin may increase estradiol concentrations, and estrogens may in turn raise cyclosporin levels. This can cause estrogenic adverse effects and cyclosporin toxicity.
How serious is the interaction between Cyclosporin and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporin trough levels and renal function when estradiol is started or stopped, and watch for estrogen excess such as breast tenderness or hypertension.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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