Drug interactions
Cyclosporin + Fexofenadine
Severity: Minor
Cyclosporin and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits P-glycoprotein and OATP transporters, which can increase fexofenadine exposure. Because fexofenadine has a wide safety margin and is non-sedating, a clinically important effect is unlikely.
What this interaction means in plain words
Cyclosporin and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Fexofenadine belongs to Respiratory.
Why it happens
Inhibition of intestinal P-glycoprotein efflux and OATP uptake by cyclosporine raises fexofenadine absorption and plasma levels.
What to do
No routine dose change is required; be aware of possible increased antihistamine effects at higher doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Cyclosporin with Fexofenadine?
MediHelp rates the interaction as minor. Cyclosporin and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine inhibits P-glycoprotein and OATP transporters, which can increase fexofenadine exposure. Because fexofenadine has a wide safety margin and is non-sedating, a clinically important effect is unlikely.
How serious is the interaction between Cyclosporin and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; be aware of possible increased antihistamine effects at higher doses.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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