Drug interactions
Cyclosporin + Finerenone
Severity: Major
Cyclosporin and Finerenone: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and may increase finerenone exposure, and both agents can raise serum potassium. The result may be clinically important hyperkalemia and reduced renal function.
What this interaction means in plain words
Cyclosporin and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Finerenone belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition raises finerenone levels, combined with additive hyperkalemic effects.
What to do
Monitor serum potassium and renal function at initiation and after dose changes, and adjust finerenone dose per labeling based on potassium. Avoid if potassium cannot be monitored reliably.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Cyclosporin with Finerenone?
MediHelp rates the interaction as major. Cyclosporin and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and may increase finerenone exposure, and both agents can raise serum potassium. The result may be clinically important hyperkalemia and reduced renal function.
How serious is the interaction between Cyclosporin and Finerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at initiation and after dose changes, and adjust finerenone dose per labeling based on potassium. Avoid if potassium cannot be monitored reliably.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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