Drug interactions
Cyclosporin + Fostamatinib
Severity: Moderate
Cyclosporin and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite, tamatinib, inhibits P-glycoprotein and may raise cyclosporine exposure. This could increase nephrotoxicity and other cyclosporine adverse effects.
What this interaction means in plain words
Cyclosporin and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Fostamatinib belongs to Oncology.
Why it happens
Tamatinib inhibits intestinal P-gp efflux, increasing cyclosporine absorption.
What to do
Monitor cyclosporine trough levels and renal function, and reduce the cyclosporine dose if concentrations or toxicity increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Cyclosporin with Fostamatinib?
MediHelp rates the interaction as moderate. Cyclosporin and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite, tamatinib, inhibits P-glycoprotein and may raise cyclosporine exposure. This could increase nephrotoxicity and other cyclosporine adverse effects.
How serious is the interaction between Cyclosporin and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function, and reduce the cyclosporine dose if concentrations or toxicity increase.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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