Drug interactions
Cyclosporin + Golimumab
Severity: Moderate
Cyclosporin and Golimumab: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of cyclosporine and golimumab leads to additive immunosuppression and a higher risk of serious and opportunistic infections. Both drugs also carry concerns about malignancy with long-term use.
What this interaction means in plain words
Cyclosporin and Golimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Golimumab belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic immunosuppression from calcineurin inhibition and TNF-alpha blockade.
What to do
Avoid the combination unless the benefit clearly outweighs the risk, and use the lowest effective doses. Screen for latent tuberculosis and hepatitis B and monitor for infection throughout treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Cyclosporin with Golimumab?
MediHelp rates the interaction as moderate. Cyclosporin and Golimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of cyclosporine and golimumab leads to additive immunosuppression and a higher risk of serious and opportunistic infections. Both drugs also carry concerns about malignancy with long-term use.
How serious is the interaction between Cyclosporin and Golimumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless the benefit clearly outweighs the risk, and use the lowest effective doses. Screen for latent tuberculosis and hepatitis B and monitor for infection throughout treatment.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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