Drug interactions
Cyclosporin + Hydrochlorothiazide
Severity: Moderate
Cyclosporin and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can add to the effects of cyclosporine on renal function, electrolytes and uric acid. Hyponatremia, hyperuricemia and decreased renal function have been reported, and thiazide-induced volume depletion may worsen cyclosporine nephrotoxicity.
What this interaction means in plain words
Cyclosporin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive effects on renal sodium handling, volume status and uric acid excretion, with possible exaggeration of cyclosporine-related renal vasoconstriction.
What to do
Monitor serum sodium, potassium, uric acid, creatinine and blood pressure regularly. Avoid volume depletion and adjust the diuretic dose if electrolyte or renal abnormalities appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Cyclosporin with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cyclosporin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can add to the effects of cyclosporine on renal function, electrolytes and uric acid. Hyponatremia, hyperuricemia and decreased renal function have been reported, and thiazide-induced volume depletion may worsen cyclosporine nephrotoxicity.
How serious is the interaction between Cyclosporin and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium, uric acid, creatinine and blood pressure regularly. Avoid volume depletion and adjust the diuretic dose if electrolyte or renal abnormalities appear.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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