Drug interactions
Cyclosporin + Levamlodipine
Severity: Moderate
Cyclosporin and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may increase levamlodipine exposure through CYP3A4 inhibition, raising the risk of hypotension and peripheral edema. Amlodipine has also been reported to raise cyclosporin concentrations in some patients.
What this interaction means in plain words
Cyclosporin and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Levamlodipine belongs to Cardiovascular.
Why it happens
Cyclosporin inhibits CYP3A4 metabolism of levamlodipine, and amlodipine may modestly raise cyclosporin levels by an incompletely defined mechanism.
What to do
Monitor blood pressure and edema, and reduce the levamlodipine dose if needed. Check cyclosporin trough concentrations after starting or changing levamlodipine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Cyclosporin with Levamlodipine?
MediHelp rates the interaction as moderate. Cyclosporin and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin may increase levamlodipine exposure through CYP3A4 inhibition, raising the risk of hypotension and peripheral edema. Amlodipine has also been reported to raise cyclosporin concentrations in some patients.
How serious is the interaction between Cyclosporin and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the levamlodipine dose if needed. Check cyclosporin trough concentrations after starting or changing levamlodipine.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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