Drug interactions
Cyclosporin + Methylprednisolone
Severity: Moderate
Cyclosporin and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine increases methylprednisolone exposure, and methylprednisolone may in turn raise cyclosporine concentrations. Seizures have been reported with high-dose methylprednisolone and cyclosporine.
What this interaction means in plain words
Cyclosporin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Methylprednisolone belongs to Endocrine.
Why it happens
Mutual inhibition of CYP3A4-mediated metabolism, with cyclosporine also inhibiting P-glycoprotein.
What to do
Monitor cyclosporine trough levels and for corticosteroid adverse effects. Be vigilant for neurotoxicity during high-dose steroid pulses and adjust doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Methylprednisolone?
MediHelp rates the interaction as moderate. Cyclosporin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine increases methylprednisolone exposure, and methylprednisolone may in turn raise cyclosporine concentrations. Seizures have been reported with high-dose methylprednisolone and cyclosporine.
How serious is the interaction between Cyclosporin and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and for corticosteroid adverse effects. Be vigilant for neurotoxicity during high-dose steroid pulses and adjust doses accordingly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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