Drug interactions
Cyclosporin + Ocrelizumab
Severity: Major
Cyclosporin and Ocrelizumab: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining ocrelizumab with cyclosporine produces additive immunosuppression and may increase the risk of serious infections. Cyclosporine is often used for transplantation or autoimmune disease where this risk is already high.
What this interaction means in plain words
Cyclosporin and Ocrelizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Ocrelizumab belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic immunosuppression from B-cell depletion and calcineurin inhibition.
What to do
Avoid if possible; if needed, monitor closely for infection and screen for hepatitis B and other latent infections before ocrelizumab. Reassess the need for both agents regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Cyclosporin with Ocrelizumab?
MediHelp rates the interaction as major. Cyclosporin and Ocrelizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining ocrelizumab with cyclosporine produces additive immunosuppression and may increase the risk of serious infections. Cyclosporine is often used for transplantation or autoimmune disease where this risk is already high.
How serious is the interaction between Cyclosporin and Ocrelizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, monitor closely for infection and screen for hepatitis B and other latent infections before ocrelizumab. Reassess the need for both agents regularly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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