Drug interactions
Cyclosporin + Ozanimod
Severity: Moderate
Cyclosporin and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits BCRP, which may increase exposure to ozanimod's active metabolites. Both drugs also affect immune function, so infection risk may be additive.
What this interaction means in plain words
Cyclosporin and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Ozanimod belongs to Central Nervous System.
Why it happens
BCRP inhibition raises ozanimod active metabolite exposure, plus additive immunosuppression.
What to do
Monitor for infections and ozanimod adverse effects such as bradycardia and liver enzyme elevation. Consider an alternative if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Cyclosporin with Ozanimod?
MediHelp rates the interaction as moderate. Cyclosporin and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits BCRP, which may increase exposure to ozanimod's active metabolites. Both drugs also affect immune function, so infection risk may be additive.
How serious is the interaction between Cyclosporin and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections and ozanimod adverse effects such as bradycardia and liver enzyme elevation. Consider an alternative if tolerability is poor.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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