Drug interactions
Cyclosporin + Repotrectinib
Severity: Major
Cyclosporin and Repotrectinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise repotrectinib exposure via CYP3A4 and P-gp inhibition. Repotrectinib is a CYP3A inducer and may lower cyclosporine concentrations, risking loss of immunosuppression.
What this interaction means in plain words
Cyclosporin and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Repotrectinib belongs to Oncology.
Why it happens
Cyclosporine inhibits CYP3A4 and P-gp, affecting repotrectinib, while repotrectinib induces CYP3A4, affecting cyclosporine.
What to do
Avoid combining where possible. If necessary, monitor cyclosporine trough levels and repotrectinib adverse effects such as neurotoxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Cyclosporin with Repotrectinib?
MediHelp rates the interaction as major. Cyclosporin and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine may raise repotrectinib exposure via CYP3A4 and P-gp inhibition. Repotrectinib is a CYP3A inducer and may lower cyclosporine concentrations, risking loss of immunosuppression.
How serious is the interaction between Cyclosporin and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If necessary, monitor cyclosporine trough levels and repotrectinib adverse effects such as neurotoxicity.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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