Drug interactions
Cyclosporin + Risperidone
Severity: Moderate
Cyclosporin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may modestly raise risperidone and its active metabolite exposure through P-glycoprotein inhibition. This could increase sedation, extrapyramidal symptoms, orthostatic hypotension or QT effects.
What this interaction means in plain words
Cyclosporin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
Cyclosporine inhibits P-glycoprotein transport of risperidone, which may increase its concentrations and CNS penetration.
What to do
Watch for sedation, extrapyramidal symptoms and hypotension, and reduce the risperidone dose if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Cyclosporin with Risperidone?
MediHelp rates the interaction as moderate. Cyclosporin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may modestly raise risperidone and its active metabolite exposure through P-glycoprotein inhibition. This could increase sedation, extrapyramidal symptoms, orthostatic hypotension or QT effects.
How serious is the interaction between Cyclosporin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for sedation, extrapyramidal symptoms and hypotension, and reduce the risperidone dose if they appear.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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