Drug interactions
Cyclosporin + Ruxolitinib
Severity: Moderate
Cyclosporin and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may modestly increase ruxolitinib exposure, which could worsen cytopenias and infection risk. Both drugs are immunosuppressive, so the combination also adds to overall immunosuppression.
What this interaction means in plain words
Cyclosporin and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Ruxolitinib belongs to Oncology.
Why it happens
Cyclosporine inhibits CYP3A4, reducing ruxolitinib metabolism; additive immunosuppression also occurs.
What to do
Monitor blood counts and signs of infection, and adjust the ruxolitinib dose according to labeling and hematologic tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Cyclosporin with Ruxolitinib?
MediHelp rates the interaction as moderate. Cyclosporin and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may modestly increase ruxolitinib exposure, which could worsen cytopenias and infection risk. Both drugs are immunosuppressive, so the combination also adds to overall immunosuppression.
How serious is the interaction between Cyclosporin and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of infection, and adjust the ruxolitinib dose according to labeling and hematologic tolerance.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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