Drug interactions
Cyclosporin + Stiripentol
Severity: Moderate
Cyclosporin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and also induces CYP3A4 and affects P-glycoprotein, so cyclosporine concentrations may become unpredictable, either raised or lowered. This can result in toxicity or loss of immunosuppressive efficacy.
What this interaction means in plain words
Cyclosporin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition/induction and P-glycoprotein inhibition by stiripentol alters cyclosporine disposition.
What to do
Monitor cyclosporine trough levels and renal function when starting or stopping stiripentol, and adjust the dose to target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Cyclosporin with Stiripentol?
MediHelp rates the interaction as moderate. Cyclosporin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and also induces CYP3A4 and affects P-glycoprotein, so cyclosporine concentrations may become unpredictable, either raised or lowered. This can result in toxicity or loss of immunosuppressive efficacy.
How serious is the interaction between Cyclosporin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when starting or stopping stiripentol, and adjust the dose to target range.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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