Drug interactions
Cyclosporin + Temsirolimus
Severity: Major
Cyclosporin and Temsirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a calcineurin inhibitor with an mTOR inhibitor produces additive immunosuppression and raises the likelihood of serious infections. Cyclosporine can also raise exposure to mTOR inhibitors and increase nephrotoxicity and metabolic adverse effects.
What this interaction means in plain words
Cyclosporin and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Additive immunosuppression from calcineurin and mTOR inhibition, with cyclosporine inhibiting CYP3A4 and P-glycoprotein and so increasing temsirolimus and sirolimus exposure.
What to do
Avoid the combination where an alternative exists; if both are required, monitor for infection, renal function and lipids and consider reducing doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Cyclosporin with Temsirolimus?
MediHelp rates the interaction as major. Cyclosporin and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a calcineurin inhibitor with an mTOR inhibitor produces additive immunosuppression and raises the likelihood of serious infections. Cyclosporine can also raise exposure to mTOR inhibitors and increase nephrotoxicity and metabolic adverse effects.
How serious is the interaction between Cyclosporin and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists; if both are required, monitor for infection, renal function and lipids and consider reducing doses.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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