Drug interactions
Cyclosporin + Trazodone
Severity: Moderate
Cyclosporin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin inhibits CYP3A4, the main pathway for trazodone clearance, so trazodone levels may rise. This can cause greater sedation, orthostatic hypotension and, rarely, QT prolongation or serotonergic effects.
What this interaction means in plain words
Cyclosporin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Trazodone belongs to Central Nervous System.
Why it happens
Cyclosporin inhibits CYP3A4-mediated metabolism of trazodone.
What to do
Begin trazodone at a low dose and titrate slowly, monitoring for sedation and hypotension. Reduce the dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Cyclosporin with Trazodone?
MediHelp rates the interaction as moderate. Cyclosporin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin inhibits CYP3A4, the main pathway for trazodone clearance, so trazodone levels may rise. This can cause greater sedation, orthostatic hypotension and, rarely, QT prolongation or serotonergic effects.
How serious is the interaction between Cyclosporin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin trazodone at a low dose and titrate slowly, monitoring for sedation and hypotension. Reduce the dose if adverse effects occur.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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