Drug interactions
Cyclosporine + Fenofibric acid
Severity: Moderate
Cyclosporine and Fenofibric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates have been associated with raised cyclosporine concentrations in some reports, and with reduced renal function in patients on cyclosporine. Cyclosporine may also raise fenofibrate-related exposure, so nephrotoxicity and muscle toxicity are concerns.
What this interaction means in plain words
Cyclosporine and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; altered renal function and transporter effects may contribute.
What to do
Monitor cyclosporine trough levels and serum creatinine when starting or stopping fenofibric acid. Consider an alternative lipid-lowering agent if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Cyclosporine with Fenofibric acid?
MediHelp rates the interaction as moderate. Cyclosporine and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates have been associated with raised cyclosporine concentrations in some reports, and with reduced renal function in patients on cyclosporine. Cyclosporine may also raise fenofibrate-related exposure, so nephrotoxicity and muscle toxicity are concerns.
How serious is the interaction between Cyclosporine and Fenofibric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and serum creatinine when starting or stopping fenofibric acid. Consider an alternative lipid-lowering agent if renal function worsens.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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