Drug interactions
Cholestyramine + Fenofibric acid
Severity: Moderate
Cholestyramine and Fenofibric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine can bind fenofibric acid and reduce its absorption, potentially diminishing lipid-lowering effect.
What this interaction means in plain words
Cholestyramine and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Fenofibric acid belongs to Cardiovascular.
Why it happens
Anion-exchange resin binds the acidic drug in the gut, reducing absorption.
What to do
Give fenofibric acid at least 1 hour before or 4 to 6 hours after cholestyramine. Monitor lipids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholestyramine
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
- Cyclosporine + Fenofibric acid Moderate
Frequently asked questions
Can I take Cholestyramine with Fenofibric acid?
MediHelp rates the interaction as moderate. Cholestyramine and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine can bind fenofibric acid and reduce its absorption, potentially diminishing lipid-lowering effect.
How serious is the interaction between Cholestyramine and Fenofibric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give fenofibric acid at least 1 hour before or 4 to 6 hours after cholestyramine. Monitor lipids.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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