Drug interactions
Chlorpropamide + Fenofibric acid
Severity: Moderate
Chlorpropamide and Fenofibric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported when they are combined. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged. Patients with low albumin or renal impairment are at higher risk.
What this interaction means in plain words
Chlorpropamide and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Fenofibric acid belongs to Cardiovascular.
Why it happens
Possible displacement from plasma protein binding combined with additive glucose-lowering pharmacodynamic effects; the evidence for each component is limited.
What to do
Monitor blood glucose more frequently when fenofibric acid is started or stopped in a patient taking chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
- Cyclosporine + Fenofibric acid Moderate
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Fenofibric acid?
MediHelp rates the interaction as moderate. Chlorpropamide and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates may enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported when they are combined. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged. Patients with low albumin or renal impairment are at higher risk.
How serious is the interaction between Chlorpropamide and Fenofibric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when fenofibric acid is started or stopped in a patient taking chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibric acid page.
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