Drug interactions
Atorvastatin + Fenofibric acid
Severity: Moderate
Atorvastatin and Fenofibric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibric acid combined with a statin modestly increases the risk of myopathy and rhabdomyolysis. Risk is higher with renal impairment, older age and higher doses.
What this interaction means in plain words
Atorvastatin and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Fenofibric acid belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic myotoxicity.
What to do
Use the lowest effective doses, monitor renal function and advise patients to report unexplained muscle pain. Check CK if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Fenofibric acid
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
- Cyclosporine + Fenofibric acid Moderate
Frequently asked questions
Can I take Atorvastatin with Fenofibric acid?
MediHelp rates the interaction as moderate. Atorvastatin and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenofibric acid combined with a statin modestly increases the risk of myopathy and rhabdomyolysis. Risk is higher with renal impairment, older age and higher doses.
How serious is the interaction between Atorvastatin and Fenofibric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, monitor renal function and advise patients to report unexplained muscle pain. Check CK if symptoms develop.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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