Drug interactions
Cholic acid + Fenofibric acid
Severity: Moderate
Cholic acid and Fenofibric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibric acid may inhibit the bile salt export pump, reducing the hepatic efflux of conjugated bile acids. Combined with exogenous cholic acid, bile salts may accumulate in hepatocytes and raise the risk of cholestatic liver injury.
What this interaction means in plain words
Cholic acid and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Fenofibric acid belongs to Cardiovascular.
Why it happens
Inhibition of the hepatic bile salt export pump (BSEP) by fenofibric acid reduces bile acid clearance from hepatocytes.
What to do
Monitor serum transaminases and bilirubin periodically during combined use. Consider an alternative lipid-lowering agent if liver tests worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
- Cyclosporine + Fenofibric acid Moderate
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Fenofibric acid?
MediHelp rates the interaction as moderate. Cholic acid and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenofibric acid may inhibit the bile salt export pump, reducing the hepatic efflux of conjugated bile acids. Combined with exogenous cholic acid, bile salts may accumulate in hepatocytes and raise the risk of cholestatic liver injury.
How serious is the interaction between Cholic acid and Fenofibric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum transaminases and bilirubin periodically during combined use. Consider an alternative lipid-lowering agent if liver tests worsen.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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