Drug interactions
Cyproheptadine + Eletriptan
Severity: Minor
Cyproheptadine and Eletriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine is a 5-HT2A antagonist and may theoretically reduce serotonin-mediated effects of triptans. Eletriptan acts mainly at 5-HT1B/1D receptors, so the clinical loss of migraine relief is uncertain and likely small.
What this interaction means in plain words
Cyproheptadine and Eletriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Eletriptan belongs to Central Nervous System.
Why it happens
Cyproheptadine's serotonin receptor antagonism may oppose serotonergic agonist effects, though eletriptan acts mainly at different receptor subtypes.
What to do
No routine change is needed. If migraine relief is inadequate while taking both, consider whether cyproheptadine is contributing and review the regimen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Eletriptan?
MediHelp rates the interaction as minor. Cyproheptadine and Eletriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyproheptadine is a 5-HT2A antagonist and may theoretically reduce serotonin-mediated effects of triptans. Eletriptan acts mainly at 5-HT1B/1D receptors, so the clinical loss of migraine relief is uncertain and likely small.
How serious is the interaction between Cyproheptadine and Eletriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. If migraine relief is inadequate while taking both, consider whether cyproheptadine is contributing and review the regimen.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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