Drug interactions
Cyproheptadine + Melatonin
Severity: Minor
Cyproheptadine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness, so together they may increase daytime sleepiness and reduce alertness. The effect is usually modest.
What this interaction means in plain words
Cyproheptadine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive sedative effects from H1 antihistamine action and melatonin receptor-mediated sleep promotion.
What to do
Advise patients to avoid driving or hazardous tasks until response is known. Reduce the dose if next-day sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Cyproheptadine with Melatonin?
MediHelp rates the interaction as minor. Cyproheptadine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents can cause drowsiness, so together they may increase daytime sleepiness and reduce alertness. The effect is usually modest.
How serious is the interaction between Cyproheptadine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks until response is known. Reduce the dose if next-day sedation occurs.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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