Drug interactions
Cyproheptadine + Modafinil
Severity: Minor
Cyproheptadine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness while cyproheptadine is sedating, so the effects may partly oppose each other. No significant harmful interaction is established.
What this interaction means in plain words
Cyproheptadine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on alertness; no established pharmacokinetic interaction.
What to do
No routine adjustment is needed. Assess alertness and symptom control and adjust therapy if either drug appears less effective.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Modafinil
Frequently asked questions
Can I take Cyproheptadine with Modafinil?
MediHelp rates the interaction as minor. Cyproheptadine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness while cyproheptadine is sedating, so the effects may partly oppose each other. No significant harmful interaction is established.
How serious is the interaction between Cyproheptadine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Assess alertness and symptom control and adjust therapy if either drug appears less effective.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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